Hello Paul,
Use the "File > Save" menu to save your changes after editing/syncing the karaoke text.
If indeed you need to save a mix, use the "File > Export Current…" menu.
More on this in the QMidi Help:
Help menu > QMidi Help > QMidi Windows > Mixer.
Mixage Software
www.mixagesoftware.com
support@mixagesoftware.com